Stability of anti-HIV Agents in Suspension

Naturally derived anti-HIV agents.

The urgent need for new anti-HIV/AIDS drugs is a global concern. In addition to obvious economical and commercial hurdles, HIV/AIDS patients are faced with multifarious difficulties associated with the currently approved anti-HIV drugs. Adverse effects, the emergence of drug resistance and the narrow spectrum of activity have limited the therapeutic usefulness of the various reverse transcripta...

synthesis of new 1,3,4-oxadiazole derivatives as anti-hiv agents

Anti-hiv Agents: a Step towards Future

Novel targets for the management of HIV infection have become increasingly relevant in view of extensive drug resistance, side effects and high pill burden of some of the conventional anti-retroviral agents. These agents include chemokine receptor antagonists and the integrase inhibitors which were recently approved for HIV treatment, as well as numerous other agents directed to previously unte...

Persulfated molecular umbrellas as anti-HIV and anti-HSV agents.

A series of persulfated molecular umbrellas have been synthesized from putrescine, spermidine, spermine, lysine, and cholic acid (1a, 2a, 3a, 4a, and 5a) and their anti-HIV and anti-HSV activities determined. Despite it size, the most active of these conjugates (5a) was able to cross phospholipid bilayers made from 1-palmitoyl-2-oleyol-sn-glycero-3-phosphocholine (POPC) and 1-palmitoyl-2-oleoyl...

Hiv Life Cycle: Targets for Anti-hiv Agents

The life cycle of human immunodeficiency virus (HIV) encompasses several crucial steps which can be considered as targets for chemotherapeutic intervention (Fig. 1.1). The life cycle starts with adsorption of virions (virus particles) to the host cell, where the viral envelope glycoprotein gp120 interacts, first, nonspecifically, with heparan sulfate; second, specifically, with the CD4 (cluster...